{"id":9133,"date":"2025-01-23T10:31:34","date_gmt":"2025-01-23T01:31:34","guid":{"rendered":"https:\/\/pro-clinic.jp\/mens\/?p=9133"},"modified":"2026-02-23T14:01:08","modified_gmt":"2026-02-23T05:01:08","slug":"exosomeandnaddiv","status":"publish","type":"post","link":"https:\/\/pro-clinic.jp\/mens\/exosomeandnaddiv\/","title":{"rendered":"\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u3068NAD\u70b9\u6ef4\u306b\u3064\u3044\u3066"},"content":{"rendered":"<header>\n<h1>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u3068NAD\u70b9\u6ef4\u306e\u9055\u3044\u3068\u306f\uff1f<\/h1>\n<\/header>\n<nav id=\"toc\">\n<h2>\u76ee\u6b21<\/h2>\n<ul>\n<li><a href=\"#introduction\">\u306f\u3058\u3081\u306b<\/a><\/li>\n<li><a href=\"#what-is-exosome\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u3068\u306f\uff1f<\/a><\/li>\n<li><a href=\"#exosome-benefits\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u306e\u52b9\u679c<\/a><\/li>\n<li><a href=\"#exosome-mechanism\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e\u4f5c\u7528\u6a5f\u5e8f<\/a><\/li>\n<li><a href=\"#exosome-source\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e\u7531\u6765\u3068\u5b89\u5168\u6027<\/a><\/li>\n<li><a href=\"#exosome-merits-demerits\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u306e\u30e1\u30ea\u30c3\u30c8\u30fb\u30c7\u30e1\u30ea\u30c3\u30c8<\/a><\/li>\n<li><a href=\"#what-is-nad\">NAD\u70b9\u6ef4\u3068\u306f\uff1f<\/a><\/li>\n<li><a href=\"#nad-benefits\">NAD\u70b9\u6ef4\u306e\u52b9\u679c<\/a><\/li>\n<li><a href=\"#nad-mechanism\">NAD\u306e\u4f5c\u7528\u6a5f\u5e8f<\/a><\/li>\n<li><a href=\"#nad-aging\">NAD\u3068\u8001\u5316\u306e\u95a2\u4fc2<\/a><\/li>\n<li><a href=\"#nad-merits-demerits\">NAD\u70b9\u6ef4\u306e\u30e1\u30ea\u30c3\u30c8\u30fb\u30c7\u30e1\u30ea\u30c3\u30c8<\/a><\/li>\n<li><a href=\"#comparison\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u3068NAD\u70b9\u6ef4\u306e\u6bd4\u8f03<\/a><\/li>\n<li><a href=\"#doctor-comment\">\u67da\ufa11\u5148\u751f\u304b\u3089\u306e\u30b3\u30e1\u30f3\u30c8<\/a><\/li>\n<li><a href=\"#references\">\u53c2\u8003\u6587\u732e<\/a><\/li>\n<li><a href=\"#conclusion\">\u307e\u3068\u3081<\/a><\/li>\n<\/ul>\n<\/nav>\n<section id=\"introduction\">\n<h2>\u306f\u3058\u3081\u306b<\/h2>\n<p>\u8fd1\u5e74\u3001\u7f8e\u5bb9\u3068\u5065\u5eb7\u3078\u306e\u610f\u8b58\u306e\u9ad8\u307e\u308a\u304b\u3089\u3001\u300c\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u300d\u3068\u300cNAD\u70b9\u6ef4\u300d\u304c\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u307e\u3059\u3002\u3069\u3061\u3089\u3082\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u3084\u5065\u5eb7\u7dad\u6301\u306b\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u308b\u70b9\u6ef4\u7642\u6cd5\u3067\u3059\u304c\u3001\u305d\u306e\u4f5c\u7528\u6a5f\u5e8f\u3084\u52b9\u679c\u306b\u306f\u9055\u3044\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u30da\u30fc\u30b8\u3067\u306f\u3001\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u3068NAD\u70b9\u6ef4\u306e\u9055\u3044\u3092\u3001\u30d7\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u306e\u67da\ufa11\u5148\u751f\u306e\u89e3\u8aac\u3092\u4ea4\u3048\u306a\u304c\u3089\u8a73\u3057\u304f\u8aac\u660e\u3057\u3066\u3044\u304d\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u6700\u65b0\u306e\u7814\u7a76\u306b\u57fa\u3065\u3044\u305f\u8a73\u7d30\u306a\u60c5\u5831\u3068\u53c2\u8003\u6587\u732e\u3092\u63b2\u8f09\u3057\u3001\u7406\u89e3\u3092\u6df1\u3081\u3066\u3044\u305f\u3060\u3051\u308b\u3088\u3046\u306b\u69cb\u6210\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/placekitten.com\/375\/250\" alt=\"\u30a4\u30f3\u30c8\u30ed\u30c0\u30af\u30b7\u30e7\u30f3\u30a4\u30e1\u30fc\u30b8\" \/><\/p>\n<\/section>\n<section id=\"what-is-exosome\">\n<h2>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u3068\u306f\uff1f<\/h2>\n<p>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u3068\u306f\u3001\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u76f4\u5f8450\u301c150nm(\u30ca\u30ce\u30e1\u30fc\u30c8\u30eb)\u306e\u5c0f\u3055\u306a\u9846\u7c92\u72b6\u306e\u7269\u8cea\u3067\u3059\u3002\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u5185\u306b\u306f\u3001\u5206\u6ccc\u5143\u306e\u7d30\u80de\u306e\u60c5\u5831\u304c\u8a70\u307e\u3063\u305f\u30de\u30a4\u30af\u30edRNA\u3084\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306a\u3069\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u7d30\u80de\u9593\u306e\u60c5\u5831\u4f1d\u9054\u306e\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u3067\u306f\u3001\u30d2\u30c8\u5e79\u7d30\u80de\u57f9\u990a\u4e0a\u6e05\u6db2\u304b\u3089\u62bd\u51fa\u30fb\u7cbe\u88fd\u3055\u308c\u305f\u9ad8\u7d14\u5ea6\u306e\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u3092\u4f53\u5185\u306b\u6295\u4e0e\u3057\u307e\u3059\u3002\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306f\u3001\u7d30\u80de\u5916\u5c0f\u80de\uff08Extracellular Vesicles: EVs\uff09\u306e\u4e00\u7a2e\u3067\u3042\u308a\u3001\u305d\u306e\u4e2d\u3067\u3082\u7279\u306b\u533b\u7642\u5206\u91ce\u3078\u306e\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/placekitten.com\/375\/250\" alt=\"\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u8aac\u660e\" \/><\/p>\n<\/section>\n<section id=\"exosome-benefits\">\n<h2>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u306e\u52b9\u679c<\/h2>\n<p>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<ul>\n<li><b>\u808c\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u4fc3\u9032\u3001\u808c\u8cea\u6539\u5584:<\/b> \u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306b\u542b\u307e\u308c\u308b\u6210\u9577\u56e0\u5b50\u3084\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u3001\u808c\u7d30\u80de\u306e\u518d\u751f\u3092\u4fc3\u9032\u3057\u3001\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u3092\u6b63\u5e38\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u30b7\u30df\u3001\u304f\u3059\u307f\u3001\u30cb\u30ad\u30d3\u8de1\u306a\u3069\u306e\u6539\u5584\u306b\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n<li><b>\u30b7\u30ef\u3001\u305f\u308b\u307f\u306e\u6539\u5584:<\/b> \u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306f\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u3084\u30a8\u30e9\u30b9\u30c1\u30f3\u306e\u7523\u751f\u3092\u4fc3\u9032\u3059\u308b\u7dda\u7dad\u82bd\u7d30\u80de\u3092\u6d3b\u6027\u5316\u3057\u3001\u808c\u306e\u30cf\u30ea\u3084\u5f3e\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u30b7\u30ef\u3084\u305f\u308b\u307f\u306e\u6539\u5584\u306b\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n<li><b>\u5275\u50b7\u6cbb\u7652\u306e\u4fc3\u9032:<\/b> \u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306f\u3001\u50b7\u3064\u3044\u305f\u7d44\u7e54\u306e\u4fee\u5fa9\u3092\u4fc3\u9032\u3057\u3001\u50b7\u8de1\u3092\u76ee\u7acb\u305f\u306a\u304f\u3059\u308b\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n<li><b>\u6297\u708e\u75c7\u4f5c\u7528:<\/b> \u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306b\u542b\u307e\u308c\u308b\u6297\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u3001\u708e\u75c7\u3092\u6291\u3048\u3001\u808c\u8352\u308c\u3084\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306a\u3069\u306e\u75c7\u72b6\u3092\u6539\u5584\u3059\u308b\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n<li><b>\u75b2\u52b4\u56de\u5fa9:<\/b> \u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306f\u3001\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u3092\u4fc3\u9032\u3057\u3001\u75b2\u52b4\u56de\u5fa9\u3092\u65e9\u3081\u308b\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n<li><b>\u514d\u75ab\u529b\u5411\u4e0a:<\/b> \u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306f\u3001\u514d\u75ab\u7d30\u80de\u3092\u6d3b\u6027\u5316\u3057\u3001\u611f\u67d3\u75c7\u306a\u3069\u306b\u5bfe\u3059\u308b\u62b5\u6297\u529b\u3092\u9ad8\u3081\u308b\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n<li><b>\u751f\u6d3b\u7fd2\u6163\u75c5\u306e\u4e88\u9632\u30fb\u6539\u5584:<\/b> \u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306f\u3001\u8840\u7cd6\u5024\u3084\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u6539\u5584\u306a\u3069\u3001\u751f\u6d3b\u7fd2\u6163\u75c5\u306e\u4e88\u9632\u3084\u6539\u5584\u306b\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<li><b>\u6bdb\u9aea\u518d\u751f(\u8584\u6bdb\u30fb\u767d\u9aea\u306e\u6539\u5584):<\/b> \u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306f\u3001\u6bdb\u5305\u7d30\u80de\u3092\u6d3b\u6027\u5316\u3057\u3001\u767a\u6bdb\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3067\u3001\u8584\u6bdb\u3084\u767d\u9aea\u306e\u6539\u5584\u306b\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n<li><b>\u8a8d\u77e5\u75c7\u306e\u4e88\u9632\u30fb\u6539\u5584:<\/b> \u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306f\u3001\u8133\u5185\u306e\u795e\u7d4c\u7d30\u80de\u3092\u4fdd\u8b77\u3057\u3001\u8a8d\u77e5\u6a5f\u80fd\u306e\u6539\u5584\u306b\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/placekitten.com\/375\/250\" alt=\"\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u52b9\u679c\" \/><\/p>\n<\/section>\n<section id=\"exosome-mechanism\">\n<h2>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e\u4f5c\u7528\u6a5f\u5e8f<\/h2>\n<p>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e\u4f5c\u7528\u6a5f\u5e8f\u306f\u3001\u4e3b\u306b\u4ee5\u4e0b\u306e3\u3064\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\n<ol>\n<li><b>\u7d30\u80de\u9593\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3:<\/b> \u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306f\u3001\u5185\u5305\u3059\u308b\u30de\u30a4\u30af\u30edRNA\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u306a\u3069\u306e\u60c5\u5831\u3092\u3001\u53d7\u3051\u53d6\u308a\u624b\u306e\u7d30\u80de\u306b\u4f1d\u9054\u3059\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u306e\u6a5f\u80fd\u3084\u5206\u5316\u3092\u5236\u5fa1\u3057\u307e\u3059\u3002<\/li>\n<li><b>\u7d30\u80de\u8868\u9762\u53d7\u5bb9\u4f53\u3068\u306e\u7d50\u5408:<\/b> \u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u8868\u9762\u306b\u5b58\u5728\u3059\u308b\u30ea\u30ac\u30f3\u30c9\u304c\u3001\u6a19\u7684\u7d30\u80de\u306e\u8868\u9762\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u5185\u306b\u30b7\u30b0\u30ca\u30eb\u3092\u4f1d\u9054\u3057\u3001\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3084\u6291\u5236\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/li>\n<li><b>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u5185\u5bb9\u7269\u306e\u653e\u51fa:<\/b> \u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u304c\u6a19\u7684\u7d30\u80de\u306b\u53d6\u308a\u8fbc\u307e\u308c\u305f\u5f8c\u3001\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u306a\u3069\u306e\u7d4c\u8def\u3067\u7d30\u80de\u5185\u306b\u53d6\u308a\u8fbc\u307e\u308c\u3001\u5185\u5305\u3059\u308b\u30de\u30a4\u30af\u30edRNA\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u306a\u3069\u3092\u653e\u51fa\u3059\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u306e\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/li>\n<\/ol>\n<p>\u3053\u308c\u3089\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u308a\u3001\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306f\u3001\u7d44\u7e54\u306e\u4fee\u5fa9\u3001\u518d\u751f\u3001\u514d\u75ab\u8abf\u6574\u306a\u3069\u3001\u69d8\u3005\u306a\u751f\u7406\u7684\u30d7\u30ed\u30bb\u30b9\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/placekitten.com\/375\/250\" alt=\"\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e\u4f5c\u7528\u6a5f\u5e8f\" \/><\/p>\n<\/section>\n<section id=\"exosome-source\">\n<h2>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e\u7531\u6765\u3068\u5b89\u5168\u6027<\/h2>\n<p>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u306b\u4f7f\u7528\u3055\u308c\u308b\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306f\u3001\u4e3b\u306b\u30d2\u30c8\u306e\u5e79\u7d30\u80de\u3092\u57f9\u990a\u3057\u305f\u969b\u306b\u5f97\u3089\u308c\u308b\u57f9\u990a\u4e0a\u6e05\u6db2\u304b\u3089\u62bd\u51fa\u30fb\u7cbe\u88fd\u3055\u308c\u307e\u3059\u3002\u5e79\u7d30\u80de\u306b\u306f\u3001\u9593\u8449\u7cfb\u5e79\u7d30\u80de\uff08MSC\uff09\u3001\u8102\u80aa\u7531\u6765\u5e79\u7d30\u80de\uff08ASC\uff09\u3001\u6b6f\u9ac4\u5e79\u7d30\u80de\u306a\u3069\u3001\u69d8\u3005\u306a\u7a2e\u985e\u304c\u3042\u308a\u3001\u305d\u308c\u305e\u308c\u7531\u6765\u3059\u308b\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e\u7279\u6027\u304c\u7570\u306a\u308a\u307e\u3059\u3002\u30d7\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u3067\u306f\u3001\u53b3\u683c\u306a\u30c9\u30ca\u30fc\u9078\u5b9a\u57fa\u6e96\u3092\u6e80\u305f\u3057\u305f\u5065\u5eb7\u306a\u65e5\u672c\u4eba\u306e\u30c9\u30ca\u30fc\u304b\u3089\u63a1\u53d6\u3055\u308c\u305f\u3001\u30d2\u30c8\u8102\u80aa\u7531\u6765\u5e79\u7d30\u80de\u57f9\u990a\u4e0a\u6e05\u6db2\u3092\u4f7f\u7528\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30a6\u30a4\u30eb\u30b9\u3084\u7d30\u83cc\u306a\u3069\u306e\u611f\u67d3\u6027\u7269\u8cea\u306e\u691c\u67fb\u3092\u5fb9\u5e95\u3057\u3001\u5b89\u5168\u6027\u3092\u78ba\u4fdd\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/placekitten.com\/375\/250\" alt=\"\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e\u7531\u6765\" \/><\/p>\n<\/section>\n<section id=\"exosome-merits-demerits\">\n<h2>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u306e\u30e1\u30ea\u30c3\u30c8\u30fb\u30c7\u30e1\u30ea\u30c3\u30c8<\/h2>\n<h3>\u30e1\u30ea\u30c3\u30c8<\/h3>\n<ul>\n<li><b>\u5e45\u5e83\u3044\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u308b:<\/b> \u4e0a\u8ff0\u306e\u3088\u3046\u306b\u3001\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u306f\u3001\u7f8e\u5bb9\u3001\u5065\u5eb7\u3001\u75be\u60a3\u4e88\u9632\u306a\u3069\u3001\u591a\u5c90\u306b\u308f\u305f\u308b\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n<li><b>\u526f\u4f5c\u7528\u304c\u5c11\u306a\u3044:<\/b> \u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306f\u3001\u3082\u3068\u3082\u3068\u4f53\u5185\u306b\u5b58\u5728\u3059\u308b\u7269\u8cea\u3067\u3042\u308b\u305f\u3081\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u306a\u3069\u306e\u526f\u4f5c\u7528\u304c\u8d77\u3053\u308a\u306b\u304f\u3044\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<li><b>\u30c0\u30a6\u30f3\u30bf\u30a4\u30e0\u304c\u307b\u3068\u3093\u3069\u306a\u3044:<\/b> \u70b9\u6ef4\u7642\u6cd5\u3067\u3042\u308b\u305f\u3081\u3001\u65bd\u8853\u5f8c\u306e\u30c0\u30a6\u30f3\u30bf\u30a4\u30e0\u306f\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093\u3002<\/li>\n<\/ul>\n<h3>\u30c7\u30e1\u30ea\u30c3\u30c8<\/h3>\n<ul>\n<li><b>\u63d0\u4f9b\u30af\u30ea\u30cb\u30c3\u30af\u3067\u54c1\u8cea\u3084\u52b9\u679c\u304c\u7570\u306a\u308b:<\/b> \u4fdd\u7ba1\u30fb\u63d0\u4f9b\u4f53\u5236\u304c\u30af\u30ea\u30cb\u30c3\u30af\u3067\u7570\u306a\u308b\u5834\u5408\u3082\u3042\u308a\u3001\u8a73\u3057\u3044\u8aac\u660e\u304c\u5fc5\u8981\u3002<\/li>\n<li><b>\u65bd\u8853\u5f8c\u306e\u5236\u7d04:<\/b>\u00a0\u52b9\u679c\u306e\u5b9f\u611f\u306b\u500b\u4eba\u5dee\u304c\u3042\u3063\u305f\u308a\u3001\u65bd\u8853\u5f8c6\u30f6\u6708\u301c\uff11\u5e74\u3067\u306e\u732e\u8840\u306f\u63a7\u3048\u305f\u65b9\u304c\u671b\u307e\u3057\u3044\u3002<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/placekitten.com\/375\/250\" alt=\"\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u30e1\u30ea\u30c3\u30c8\u30c7\u30e1\u30ea\u30c3\u30c8\" \/><\/p>\n<\/section>\n<section id=\"what-is-nad\">\n<h2>NAD\u70b9\u6ef4\u3068\u306f\uff1f<\/h2>\n<p>NAD\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30a2\u30c7\u30cb\u30f3\u30b8\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff09\u306f\u3001\u5168\u3066\u306e\u751f\u7269\u306e\u7d30\u80de\u5185\u306b\u5b58\u5728\u3059\u308b\u88dc\u9175\u7d20\u3067\u3059\u3002NAD\u306f\u3001\u9178\u5316\u9084\u5143\u53cd\u5fdc\u306b\u95a2\u4e0e\u3057\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u3084DNA\u4fee\u5fa9\u306a\u3069\u3001\u7d30\u80de\u306e\u751f\u547d\u7dad\u6301\u306b\u4e0d\u53ef\u6b20\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002NAD\u70b9\u6ef4\u3067\u306f\u3001\u9ad8\u6fc3\u5ea6\u306eNAD\u3092\u4f53\u5185\u306b\u76f4\u63a5\u6295\u4e0e\u3059\u308b\u3053\u3068\u3067\u3001\u52a0\u9f62\u3084\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\u6e1b\u5c11\u3057\u305fNAD\u30ec\u30d9\u30eb\u3092\u56de\u5fa9\u3055\u305b\u3001\u7d30\u80de\u6a5f\u80fd\u3092\u6d3b\u6027\u5316\u3055\u305b\u307e\u3059\u3002NAD\u306f\u3001NADH\uff08\u9084\u5143\u578b\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30a2\u30c7\u30cb\u30f3\u30b8\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff09\u3068\u306e\u76f8\u4e92\u5909\u63db\u306b\u3088\u3063\u3066\u3001\u96fb\u5b50\u306e\u6388\u53d7\u3092\u884c\u3044\u3001\u7d30\u80de\u5185\u306e\u9178\u5316\u9084\u5143\u72b6\u614b\u3092\u8abf\u7bc0\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001NAD\u306f\u3001\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u907a\u4f1d\u5b50\u3068\u547c\u3070\u308c\u308b\u9577\u5bff\u907a\u4f1d\u5b50\u3092\u6d3b\u6027\u5316\u3059\u308b\u88dc\u56e0\u5b50\u3068\u3057\u3066\u3082\u6a5f\u80fd\u3057\u307e\u3059\u3002\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u907a\u4f1d\u5b50\u306f\u3001\u7d30\u80de\u306e\u8001\u5316\u3092\u9045\u3089\u305b\u3001\u5bff\u547d\u3092\u5ef6\u3070\u3059\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/placekitten.com\/375\/250\" alt=\"NAD\u8aac\u660e\" \/><\/p>\n<\/section>\n<section id=\"nad-benefits\">\n<h2>NAD\u70b9\u6ef4\u306e\u52b9\u679c<\/h2>\n<p>NAD\u70b9\u6ef4\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<ul>\n<li><b>\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u306e\u4fc3\u9032\u3001\u75b2\u52b4\u56de\u5fa9:<\/b> NAD\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u304a\u3051\u308bATP\uff08\u30a2\u30c7\u30ce\u30b7\u30f3\u4e09\u30ea\u30f3\u9178\uff09\u7523\u751f\u306b\u5fc5\u9808\u306e\u88dc\u9175\u7d20\u3067\u3042\u308a\u3001NAD\u30ec\u30d9\u30eb\u3092\u9ad8\u3081\u308b\u3053\u3068\u3067\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u304c\u4fc3\u9032\u3055\u308c\u3001\u75b2\u52b4\u56de\u5fa9\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n<li><b>\u4ee3\u8b1d\u306e\u5411\u4e0a\u3001\u30c0\u30a4\u30a8\u30c3\u30c8\u52b9\u679c:<\/b> NAD\u306f\u3001\u7cd6\u8cea\u3084\u8102\u8cea\u306e\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3059\u308b\u9175\u7d20\u306e\u50cd\u304d\u3092\u52a9\u3051\u3001\u4ee3\u8b1d\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u30c0\u30a4\u30a8\u30c3\u30c8\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n<li><b>\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u5316\u306b\u3088\u308b\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u52b9\u679c:<\/b> NAD\u306f\u3001\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u907a\u4f1d\u5b50\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u306e\u8001\u5316\u3092\u9045\u3089\u305b\u3001\u30b7\u30ef\u3084\u305f\u308b\u307f\u306a\u3069\u306e\u6539\u5584\u306b\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n<li><b>DNA\u4fee\u5fa9\u6a5f\u80fd\u306e\u5411\u4e0a:<\/b> NAD\u306f\u3001DNA\u4fee\u5fa9\u306b\u95a2\u4e0e\u3059\u308b\u9175\u7d20\u306e\u50cd\u304d\u3092\u52a9\u3051\u3001\u7d30\u80de\u306e\u640d\u50b7\u3092\u4fee\u5fa9\u3057\u3001\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n<li><b>\u8133\u6a5f\u80fd\u306e\u6539\u5584\u3001\u96c6\u4e2d\u529b\u30fb\u8a18\u61b6\u529b\u306e\u5411\u4e0a:<\/b> NAD\u306f\u3001\u8133\u5185\u306e\u795e\u7d4c\u7d30\u80de\u306e\u6a5f\u80fd\u3092\u6539\u5584\u3057\u3001\u96c6\u4e2d\u529b\u3084\u8a18\u61b6\u529b\u306e\u5411\u4e0a\u306b\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n<li><b>\u7761\u7720\u306e\u8cea\u306e\u6539\u5584:<\/b> NAD\u306f\u3001\u4f53\u5185\u6642\u8a08\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3001\u7761\u7720\u306e\u8cea\u3092\u6539\u5584\u3059\u308b\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n<li><b>\u6162\u6027\u75be\u60a3\u306e\u4e88\u9632\u30fb\u6539\u5584:<\/b> NAD\u306f\u3001\u7cd6\u5c3f\u75c5\u3084\u5fc3\u8840\u7ba1\u75be\u60a3\u306a\u3069\u306e\u6162\u6027\u75be\u60a3\u306e\u4e88\u9632\u3084\u6539\u5584\u306b\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<li><b>\u6297\u9178\u5316\u4f5c\u7528:<\/b> NAD\u306f\u3001\u7d30\u80de\u5185\u306e\u6d3b\u6027\u9178\u7d20\u3092\u9664\u53bb\u3057\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304b\u3089\u7d30\u80de\u3092\u4fdd\u8b77\u3059\u308b\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n<li><b>\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u306a\u3069\u306e\u4f9d\u5b58\u75c7\u306e\u6539\u5584:<\/b> NAD\u306f\u3001\u8133\u5185\u306e\u5831\u916c\u7cfb\u306b\u4f5c\u7528\u3057\u3001\u4f9d\u5b58\u75c7\u306e\u6539\u5584\u306b\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/placekitten.com\/375\/250\" alt=\"NAD\u52b9\u679c\" \/><\/p>\n<\/section>\n<section id=\"nad-mechanism\">\n<h2>NAD\u306e\u4f5c\u7528\u6a5f\u5e8f<\/h2>\n<p>NAD\u306e\u4f5c\u7528\u6a5f\u5e8f\u306f\u3001\u4e3b\u306b\u4ee5\u4e0b\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\n<ol>\n<li><b>\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d:<\/b> NAD\u306f\u3001\u89e3\u7cd6\u7cfb\u3001TCA\u56de\u8def\u3001\u96fb\u5b50\u4f1d\u9054\u7cfb\u306a\u3069\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u7d4c\u8def\u306b\u304a\u3044\u3066\u3001\u88dc\u9175\u7d20\u3068\u3057\u3066\u50cd\u304d\u3001ATP\u7523\u751f\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002<\/li>\n<li><b>\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u5316:<\/b> NAD\u306f\u3001\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u5316\u306b\u5fc5\u8981\u306a\u88dc\u56e0\u5b50\u3067\u3042\u308a\u3001\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u306e\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u306e\u8001\u5316\u6291\u5236\u3001DNA\u4fee\u5fa9\u3001\u4ee3\u8b1d\u8abf\u7bc0\u306a\u3069\u306e\u4f5c\u7528\u3092\u767a\u63ee\u3057\u307e\u3059\u3002<\/li>\n<li><b>DNA\u4fee\u5fa9:<\/b> NAD\u306f\u3001DNA\u4fee\u5fa9\u306b\u95a2\u4e0e\u3059\u308bPARP\uff08\u30dd\u30ea\u30a2\u30c7\u30ce\u30b7\u30f3\u4e8c\u30ea\u30f3\u9178\u30ea\u30dc\u30fc\u30b9\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\uff09\u306a\u3069\u306e\u9175\u7d20\u306e\u57fa\u8cea\u3068\u306a\u308a\u3001DNA\u640d\u50b7\u306e\u4fee\u5fa9\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002<\/li>\n<li><b>\u7d30\u80de\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054:<\/b> NAD\u306f\u3001\u7d30\u80de\u5185\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u6fc3\u5ea6\u3092\u8abf\u7bc0\u3059\u308b\u306a\u3069\u3001\u7d30\u80de\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u3082\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ol>\n<p>\u3053\u308c\u3089\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u308a\u3001NAD\u306f\u3001\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u3001\u8001\u5316\u6291\u5236\u3001DNA\u4fee\u5fa9\u3001\u7d30\u80de\u6a5f\u80fd\u306e\u7dad\u6301\u306a\u3069\u3001\u69d8\u3005\u306a\u751f\u7406\u7684\u30d7\u30ed\u30bb\u30b9\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/placekitten.com\/375\/250\" alt=\"NAD\u306e\u4f5c\u7528\u6a5f\u5e8f\" \/><\/p>\n<\/section>\n<section id=\"nad-aging\">\n<h2>NAD\u3068\u8001\u5316\u306e\u95a2\u4fc2<\/h2>\n<p>NAD\u30ec\u30d9\u30eb\u306f\u3001\u52a0\u9f62\u3068\u3068\u3082\u306b\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002NAD\u30ec\u30d9\u30eb\u306e\u4f4e\u4e0b\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3001\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u4f4e\u4e0b\u3001DNA\u640d\u50b7\u306e\u84c4\u7a4d\u306a\u3069\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u8001\u5316\u306e\u9032\u884c\u3084\u52a0\u9f62\u306b\u4f34\u3046\u75be\u60a3\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001NAD\u30ec\u30d9\u30eb\u3092\u7dad\u6301\u307e\u305f\u306f\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u306f\u3001\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u3084\u5065\u5eb7\u5bff\u547d\u306e\u5ef6\u4f38\u306b\u52b9\u679c\u7684\u3067\u3042\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/placekitten.com\/375\/250\" alt=\"NAD\u3068\u8001\u5316\" \/><\/p>\n<\/section>\n<section id=\"nad-merits-demerits\">\n<h2>NAD\u70b9\u6ef4\u306e\u30e1\u30ea\u30c3\u30c8\u30fb\u30c7\u30e1\u30ea\u30c3\u30c8<\/h2>\n<h3>\u30e1\u30ea\u30c3\u30c8<\/h3>\n<ul>\n<li><b>\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u306e\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u308b:<\/b> NAD\u70b9\u6ef4\u306f\u3001\u52a0\u9f62\u306b\u3088\u3063\u3066\u6e1b\u5c11\u3059\u308bNAD\u3092\u76f4\u63a5\u88dc\u5145\u3059\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u306e\u82e5\u8fd4\u308a\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n<li><b>\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u3092\u4fc3\u9032\u3057\u3001\u75b2\u52b4\u56de\u5fa9\u3084\u4ee3\u8b1d\u5411\u4e0a\u306b\u52b9\u679c\u7684:<\/b> NAD\u306f\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u306b\u4e0d\u53ef\u6b20\u306a\u88dc\u9175\u7d20\u3067\u3042\u308a\u3001NAD\u70b9\u6ef4\u306b\u3088\u3063\u3066\u3001\u75b2\u52b4\u56de\u5fa9\u3084\u4ee3\u8b1d\u306e\u5411\u4e0a\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n<li><b>\u5e45\u5e83\u3044\u5065\u5eb7\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u308b:<\/b> \u4e0a\u8ff0\u306e\u3088\u3046\u306b\u3001NAD\u70b9\u6ef4\u306f\u3001\u8133\u6a5f\u80fd\u6539\u5584\u3001\u7761\u7720\u306e\u8cea\u6539\u5584\u3001\u6162\u6027\u75be\u60a3\u4e88\u9632\u306a\u3069\u3001\u69d8\u3005\u306a\u5065\u5eb7\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/li>\n<\/ul>\n<h3>\u30c7\u30e1\u30ea\u30c3\u30c8<\/h3>\n<ul>\n<li><b>\u70b9\u6ef4\u4e2d\u306b\u8840\u7ba1\u75db\u3092\u611f\u3058\u308b\u3053\u3068\u304c\u3042\u308b:<\/b> NAD\u70b9\u6ef4\u3067\u306f\u3001\u9ad8\u6fc3\u5ea6\u306eNAD\u3092\u6295\u4e0e\u3059\u308b\u305f\u3081\u3001\u70b9\u6ef4\u4e2d\u306b\u8840\u7ba1\u75db\u3092\u611f\u3058\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u4ed6\u3001\u767a\u71b1\u30fb\u982d\u75db\u30fb\u52d5\u60b8\u30fb\u80f8\u306e\u3064\u304b\u3048\u611f\u304c\u8d77\u304d\u308b\u5834\u5408\u3082\u3002<\/li>\n<li><b>\u52b9\u679c\u306b\u500b\u4eba\u5dee\u304c\u5927\u304d\u3044:<\/b> NAD\u70b9\u6ef4\u306f\u3001\u300c\u75b2\u52b4\u611f\u304c\u53d6\u308c\u305f\u300d\u300c\u96c6\u4e2d\u529b\u304c\u4e0a\u304c\u3063\u305f\u300d\u3068\u611f\u3058\u308b\u4eba\u3082\u3044\u308c\u3070\u3001\u300c\u3042\u307e\u308a\u5909\u5316\u304c\u306a\u3044\u300d\u3068\u611f\u3058\u308b\u4eba\u3082\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/placekitten.com\/375\/250\" alt=\"NAD\u30e1\u30ea\u30c3\u30c8\u30c7\u30e1\u30ea\u30c3\u30c8\" \/><\/p>\n<\/section>\n<section id=\"comparison\">\n<h2>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u3068NAD\u70b9\u6ef4\u306e\u6bd4\u8f03<\/h2>\n<p>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u3068NAD\u70b9\u6ef4\u306f\u3001\u3069\u3061\u3089\u3082\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u3084\u5065\u5eb7\u7dad\u6301\u306b\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u308b\u70b9\u6ef4\u7642\u6cd5\u3067\u3059\u304c\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u9055\u3044\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<div class=\"s_table\"><table>\n<thead>\n<tr>\n<th>\u9805\u76ee<\/th>\n<th>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4<\/th>\n<th>NAD\u70b9\u6ef4<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u4e3b\u6210\u5206<\/td>\n<td>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\uff08\u30de\u30a4\u30af\u30edRNA\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306a\u3069\u3092\u542b\u3080\uff09<\/td>\n<td>NAD\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30a2\u30c7\u30cb\u30f3\u30b8\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff09<\/td>\n<\/tr>\n<tr>\n<td>\u4f5c\u7528\u6a5f\u5e8f<\/td>\n<td>\u7d30\u80de\u9593\u306e\u60c5\u5831\u4f1d\u9054\u3092\u4fc3\u9032\u3057\u3001\u7d30\u80de\u306e\u6a5f\u80fd\u3084\u5206\u5316\u3092\u5236\u5fa1<\/td>\n<td>\u7d30\u80de\u5185\u306eNAD\u30ec\u30d9\u30eb\u3092\u5897\u52a0\u3055\u305b\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u3001\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u5316\u3001DNA\u4fee\u5fa9\u306a\u3069\u3092\u4fc3\u9032<\/td>\n<\/tr>\n<tr>\n<td>\u671f\u5f85\u3055\u308c\u308b\u52b9\u679c<\/td>\n<td>\u808c\u8cea\u6539\u5584\u3001\u5275\u50b7\u6cbb\u7652\u3001\u6297\u708e\u75c7\u3001\u514d\u75ab\u529b\u5411\u4e0a\u3001\u75b2\u52b4\u56de\u5fa9\u3001\u751f\u6d3b\u7fd2\u6163\u75c5\u4e88\u9632\u306a\u3069\u3001\u3088\u308a\u5e83\u7bc4\u306a\u4f5c\u7528<\/td>\n<td>\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u4fc3\u9032\u3001\u4ee3\u8b1d\u5411\u4e0a\u3001\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\uff08\u7279\u306b\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u907a\u4f1d\u5b50\u6d3b\u6027\u5316\uff09\u3001\u8133\u6a5f\u80fd\u6539\u5584\u3001\u75b2\u52b4\u56de\u5fa9\u306a\u3069\u3001\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306b\u7279\u5316\u3057\u305f\u4f5c\u7528<\/td>\n<\/tr>\n<tr>\n<td>\u4f5c\u7528\u306e\u7279\u5fb4<\/td>\n<td>\u7d30\u80de\u5916\u304b\u3089\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u3088\u308b\u7d30\u80de\u6a5f\u80fd\u306e\u8abf\u6574<\/td>\n<td>\u7d30\u80de\u5185\u4ee3\u8b1d\u306e\u6d3b\u6027\u5316\u306b\u3088\u308b\u7d30\u80de\u6a5f\u80fd\u306e\u5411\u4e0a<\/td>\n<\/tr>\n<tr>\n<td>\u30a8\u30d3\u30c7\u30f3\u30b9<\/td>\n<td>\u6bd4\u8f03\u7684\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u3067\u3042\u308a\u3001\u7814\u7a76\u6bb5\u968e\u306e\u90e8\u5206\u3082\u591a\u3044\u304c\u3001\u8fd1\u5e74\u6025\u901f\u306b\u7814\u7a76\u304c\u9032\u5c55\u3057\u3066\u3044\u308b<\/td>\n<td>NAD\u306e\u5f79\u5272\u306b\u3064\u3044\u3066\u306f\u53e4\u304f\u304b\u3089\u7814\u7a76\u3055\u308c\u3066\u304a\u308a\u3001\u57fa\u790e\u7814\u7a76\u30ec\u30d9\u30eb\u3067\u306f\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u8c4a\u5bcc\u3002\u81e8\u5e8a\u8a66\u9a13\u3082\u591a\u304f\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/td>\n<\/tr>\n<tr>\n<td>\u8cbb\u7528<\/td>\n<td>\u81ea\u7531\u8a3a\u7642\u306e\u305f\u3081\u533b\u9662\u306b\u3088\u308b<\/td>\n<td>\u81ea\u7531\u8a3a\u7642\u306e\u305f\u3081\u533b\u9662\u306b\u3088\u308b<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/placekitten.com\/375\/250\" alt=\"\u6bd4\u8f03\u8868\" \/><\/p>\n<\/section>\n<section id=\"doctor-comment\">\n<h2>\u67da\ufa11\u5148\u751f\u304b\u3089\u306e\u30b3\u30e1\u30f3\u30c8<\/h2>\n<p>\u300c\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u3068NAD\u70b9\u6ef4\u306f\u3001\u3069\u3061\u3089\u3082\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u82e5\u8fd4\u308a\u3084\u5065\u5eb7\u5897\u9032\u3092\u56f3\u308b\u3001\u975e\u5e38\u306b\u52b9\u679c\u7684\u306a\u6cbb\u7642\u6cd5\u3067\u3059\u3002\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u306f\u3001\u7d30\u80de\u9593\u306e\u60c5\u5831\u4f1d\u9054\u3092\u30b9\u30e0\u30fc\u30ba\u306b\u3059\u308b\u3053\u3068\u3067\u3001\u7d44\u7e54\u306e\u4fee\u5fa9\u3084\u518d\u751f\u3092\u4fc3\u9032\u3057\u3001\u3088\u308a\u5e83\u7bc4\u306a\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002\u4e00\u65b9\u3001NAD\u70b9\u6ef4\u306f\u3001\u7d30\u80de\u5185\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u5de5\u5834\u3067\u3042\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u50cd\u304d\u3092\u9ad8\u3081\u3001\u7d30\u80de\u306e\u6a5f\u80fd\u3092\u6d3b\u6027\u5316\u3057\u3001\u7279\u306b\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3084\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u5316\u306b\u52b9\u679c\u7684\u3067\u3059\u3002\u3069\u3061\u3089\u306e\u70b9\u6ef4\u304c\u9069\u3057\u3066\u3044\u308b\u304b\u306f\u3001\u60a3\u8005\u69d8\u306e\u304a\u60a9\u307f\u3084\u76ee\u7684\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u808c\u306e\u82e5\u8fd4\u308a\u3084\u5275\u50b7\u6cbb\u7652\u3092\u91cd\u8996\u3059\u308b\u5834\u5408\u306f\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u3001\u75b2\u52b4\u56de\u5fa9\u3084\u4ee3\u8b1d\u5411\u4e0a\u3001\u8133\u6a5f\u80fd\u306e\u6539\u5584\u3092\u91cd\u8996\u3059\u308b\u5834\u5408\u306fNAD\u70b9\u6ef4\u304c\u9069\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u4e21\u65b9\u306e\u70b9\u6ef4\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u76f8\u4e57\u52b9\u679c\u3082\u671f\u5f85\u3067\u304d\u307e\u3059\u3002\u30d7\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u3067\u306f\u3001\u6700\u65b0\u306e\u7814\u7a76\u306b\u57fa\u3065\u3044\u305f\u77e5\u8b58\u3068\u8c4a\u5bcc\u306a\u7d4c\u9a13\u3092\u3082\u3068\u306b\u3001\u60a3\u8005\u69d8\u4e00\u4eba\u3072\u3068\u308a\u306b\u6700\u9069\u306a\u6cbb\u7642\u30d7\u30e9\u30f3\u3092\u3054\u63d0\u6848\u3044\u305f\u3057\u307e\u3059\u3002\u305c\u3072\u304a\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u300d<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/placekitten.com\/375\/250\" alt=\"\u67da\ufa11\u5148\u751f\" \/><\/p>\n<p>\u30d7\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u9662\u9577\u3000\u5f62\u6210\u5916\u79d1\u5c02\u9580\u533b\u3000\u67da\ufa11\u4e00\u8f1d<\/p>\n<\/section>\n<section id=\"references\">\n<h2>\u53c2\u8003\u6587\u732e<\/h2>\n<ul>\n<li>Th\u00e9ry C, Witwer KW, Aikawa E, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7(1):1535750.<\/li>\n<li>Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367(6478):eaau6977.<\/li>\n<li>Y\u00e1\u00f1ez-M\u00f3 M, Siljander PR, Andreu Z, et al. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015;4:27066.<\/li>\n<li>Rajendran L, Honsho M, Zahn TR, et al. Alzheimer&#8217;s disease beta-amyloid peptides are released in association with exosomes. Proc Natl Acad Sci U S A. 2006;103(30):11172-11177.<\/li>\n<li>Valadi H, Ekstr\u00f6m K, Bossios A, Sj\u00f6strand M, Lee JJ, L\u00f6tvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9(6):654-659.<\/li>\n<li>Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22(2):119-141.<\/li>\n<li>Yoshino J, Baur JA, Imai SI. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab. 2018;27(3):513-528.<\/li>\n<li>Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 2014;24(8):464-471.<\/li>\n<li>Verdin E. NAD\u207a in aging, metabolism, and neurodegeneration. Science. 2015;350(6265):1208-1213.<\/li>\n<li>* \u4e0a\u8a18\u306f\u3042\u304f\u307e\u3067\u3082\u4e00\u4f8b\u3067\u3059\u3002\u4ed6\u306b\u3082\u591a\u6570\u306e\u53c2\u8003\u6587\u732e\u304c\u5b58\u5728\u3057\u307e\u3059\u3002<\/li>\n<li>* \u8ad6\u6587\u691c\u7d22\u306b\u306f\u3001PubMed\u306a\u3069\u306e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u304c\u4fbf\u5229\u3067\u3059\u3002<\/li>\n<\/ul>\n<\/section>\n<section id=\"conclusion\">\n<h2>\u307e\u3068\u3081<\/h2>\n<p>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u3068NAD\u70b9\u6ef4\u306f\u3001\u3069\u3061\u3089\u3082ED\u6cbb\u7642\u3001\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u3084\u5065\u5eb7\u5897\u9032\u306b\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u308b\u6700\u5148\u7aef\u306e\u70b9\u6ef4\u7642\u6cd5\u3067\u3059\u3002\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u306f\u3001\u7d30\u80de\u9593\u306e\u60c5\u5831\u4f1d\u9054\u3092\u4fc3\u9032\u3057\u3001\u7d44\u7e54\u306e\u4fee\u5fa9\u3084\u518d\u751f\u3092\u4fc3\u3059\u3053\u3068\u3067\u3001\u5e45\u5e83\u3044\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002\u4e00\u65b9\u3001NAD\u70b9\u6ef4\u306f\u3001\u7d30\u80de\u5185\u306eNAD\u30ec\u30d9\u30eb\u3092\u9ad8\u3081\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u3084\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u5316\u306a\u3069\u3092\u901a\u3058\u3066\u3001\u7d30\u80de\u6a5f\u80fd\u3092\u5411\u4e0a\u3055\u305b\u307e\u3059\u3002\u305d\u308c\u305e\u308c\u306e\u7279\u5fb4\u3084\u52b9\u679c\u3092\u7406\u89e3\u3057\u3001\u3054\u81ea\u8eab\u306e\u76ee\u7684\u3084\u4f53\u8cea\u306b\u5408\u3063\u305f\u6cbb\u7642\u6cd5\u3092\u9078\u3076\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002\u30d7\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u3067\u306f\u3001\u7d4c\u9a13\u8c4a\u5bcc\u306a\u533b\u5e2b\u304c\u3001\u60a3\u8005\u69d8\u4e00\u4eba\u3072\u3068\u308a\u306b\u6700\u9069\u306a\u6cbb\u7642\u30d7\u30e9\u30f3\u3092\u3054\u63d0\u6848\u3044\u305f\u3057\u307e\u3059\u3002\u6700\u65b0\u306e\u7814\u7a76\u306b\u57fa\u3065\u3044\u305f\u8a73\u7d30\u306a\u60c5\u5831\u63d0\u4f9b\u3068\u3001\u4e01\u5be7\u306a\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3092\u5fc3\u304c\u3051\u3066\u304a\u308a\u307e\u3059\u306e\u3067\u3001\u305c\u3072\u304a\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/placekitten.com\/375\/250\" alt=\"\u307e\u3068\u3081\" \/><\/p>\n<\/section>\n<footer>\u00a9 2024 \u30d7\u30ed\u30af\u30ea\u30cb\u30c3\u30af<\/p>\n<\/footer>\n<p><script><br \/>\n        \/\/ \u30b9\u30e0\u30fc\u30b9\u30b9\u30af\u30ed\u30fc\u30eb<br \/>\n        document.querySelectorAll('a[href^=\"#\"]').forEach(anchor => {<br \/>\n            anchor.addEventListener('click', function (e) {<br \/>\n                e.preventDefault();<\/p>\n<p>                const targetId = this.getAttribute('href');<br \/>\n                const targetElement = document.querySelector(targetId);<\/p>\n<p>                if (targetElement) {<br \/>\n                    \/\/ \u30d8\u30c3\u30c0\u30fc\u306e\u9ad8\u3055\u3092\u53d6\u5f97\uff08\u56fa\u5b9a\u30d8\u30c3\u30c0\u30fc\u306e\u5834\u5408\uff09<br \/>\n                    \/\/ const headerHeight = document.querySelector('header').offsetHeight;<br \/>\n                    const headerHeight = 0; 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